Anti-L1CAM Antibody [SPM275] (A249220)

Anti-L1CAM Antibody [SPM275]

Mouse monoclonal [SPM275] antibody to L1CAM.

This antibody recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Flow Cytometry, IF, IHC-Fr

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-Fr: 1-2 µg/ml

Human

Homogenous suspension of 16-week human fetal brain.

Mouse

Monoclonal

SPM275

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

220-240 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-L1CAM Antibody [SPM275] - BSA and Azide free (A252400).

Antigen identified by monoclonal, CAML1, CD171, CD171 antigen, HSAS, HSAS1, Hyd, L1, L1 cell adhesion molecule, L1-NCAM, L1CAM_HUMAN, MASA, MIC5, N CAML1, N-CAM-L1, NCAM-L1, NCAML1, Nerve-growth factor-inducible large external glycoprotein, Neural cell adhesion molecule L1, NILE, OTTHUMP00000025992, S10, SPG1