Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free (A278459)

Name: Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free
Brand: Antibodies.com
SKU: A278459
Price: 525.0 USD
Availability: InStock

Enlarge Image

$525

Mouse monoclonal [LAMC1/3162] antibody to Laminin gamma 1 for IHC-P.

100% Guarantee

Price Match Guarantee

Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

Contact Us

Telephone

+1 (314) 370-6046

orders@antibodies.com

Guarantees

100% Quality Guarantee

Price Match Guarantee

Tags:

Monospecific Antibody

Specifications

Name

Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free

Description

Mouse monoclonal [LAMC1/3162] antibody to Laminin gamma 1.

Specificity

Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of alpha, beta, and gamma chains. This MAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Murine EHS laminin preparation.

Host

Mouse

Clonality

Monoclonal

Clone ID

LAMC1/3162

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Molecular Weight

210 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Laminin gamma 1 Antibody [LAMC1/3162] (A277871).

Synonyms

LAMB2, lamc1, LAMC1_HUMAN, Laminin B2 chain, Laminin subunit gamma-1, Laminin, gamma 1 (formerly LAMB2), Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, Laminin-3 subunit gamma, Laminin-4 subunit gamma, Laminin-6 subunit gamma, Laminin-7 subunit gamma, Laminin-8 subunit gamma, Laminin-9 subunit gamma, MGC87297, S-LAM gamma, S-laminin subunit gamma

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (2)

Enlarge Image

Figure 1: Immunohistochemistry - Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free (A278459)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue using Anti-Laminin gamma 1 Antibody [LAMC1/3162].

Enlarge Image

Figure 2: Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free (A278459)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Laminin gamma 1 Antibody [LAMC1/3162]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Publishing research using Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free (A278459)? Please let us know so that we can list the citation on this page.