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Anti-LRP4 Antibody

Rabbit polyclonal antibody to LRP4 from ABclonal (A10172).
Name: Anti-LRP4 Antibody
Description: Rabbit polyclonal antibody to LRP4.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human LRP4.
Protein Length: 1905
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
Tissue Specificity: Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.
Involvement in Disease: Cenani-Lenz syndactyly syndrome: A congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs. It is characterized by fusion and disorganization of metacarpal and phalangeal bones, radius and ulnar shortening, radioulnar synostosis, and severe syndactyly of hands and feet.

Sclerosteosis 2: A sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.

Myasthenic syndrome, congenital, 17: A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort.
Sequence Similarities: Belongs to the LDLR family.
Cellular Location: Membrane.
UniProt: O75096
Gene ID: 4038
Synonyms: activated protease fragment Antibody
ATC 2 Antibody
ATC2 Antibody
Atrial natriuretic peptide-converting enzyme Antibody
Atrial natriuteric peptide converting enzyme Antibody
Corin Antibody
Corin serine peptidase Antibody
CRN Antibody
Heart specific serine proteinase Antibody
Heart specific serine proteinase ATC2 Antibody
Heart-specific serine proteinase ATC2 Antibody
KIAA0816 Antibody
LDLR dan Antibody
Low density lipoprotein receptor related protein 4 Antibody
Low-density lipoprotein receptor-related protein 4 Antibody
Lrp 4 Antibody
LRP-4 Antibody
LRP10 Antibody
LRP4_HUMAN Antibody
MEGF7 Antibody
MGC119742 Antibody
Multiple epidermal growth factor like domains 7 Antibody
Multiple epidermal growth factor-like domains 7 Antibody
Pro ANP convertase Antibody
Pro ANP converting enzyme Antibody
Pro-ANP-converting enzyme Antibody
TMPRSS 10 Antibody
TMPRSS10 Antibody
Transmembrane protease serine 10 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cell lines, using LRP4 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (1)
Description: Goat polyclonal antibody to LRP4.
Application: ELISA, WB, IHC
Host: Goat
Isotype: IgG
Reactivity: Human


Description: Rabbit polyclonal antibody to CORIN.
Application: WB
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to LRP10
Application: IHC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from internal of human LRP10.

£180 – £234

Please Note: Anti-LRP4 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10172
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £35 to Europe