Anti-MDM2 Antibody [MDM2/3277] (A277704)

Anti-MDM2 Antibody [MDM2/3277]

Mouse monoclonal [MDM2/3277] antibody to MDM2.

MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 126-254, of human MDM2. The exact sequence is proprietary.

Mouse

Monoclonal

MDM2/3277

IgG1

kappa

Unconjugated

200 µg/ml

~90 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MDM2 Antibody [MDM2/3277] - BSA and Azide free (A278292).

ACTFS, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Hdm 2, Hdm2, HDMX, MDM 2, MDM2 oncogene E3 ubiquitin protein ligase, Mdm2 p53 E3 ubiquitin protein ligase homolog, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, MDM2BP, MDM2_HUMAN, Mouse Double Minute 2, MTBP, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, p53 Binding Protein Mdm2, p53-binding protein Mdm2, Ubiquitin protein ligase E3 Mdm2