Anti-MDM2 Antibody [MDM2/8221] (A315291)

$765

Mouse monoclonal [MDM2/8221] antibody to MDM2 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-MDM2 Antibody [MDM2/8221]
Description
Mouse monoclonal [MDM2/8221] antibody to MDM2.
Specificity
MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.
Applications
IHC-P
Positive Control
Human pancreas.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant human MDM2 protein fragment (around Amino Acids 1-300). The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
MDM2/8221
Isotype
IgG2
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
~90 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
ACTFS, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Hdm 2, Hdm2, HDMX, MDM 2, MDM2 oncogene E3 ubiquitin protein ligase, Mdm2 p53 E3 ubiquitin protein ligase homolog, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, MDM2BP, MDM2_HUMAN, Mouse Double Minute 2, MTBP, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, p53 Binding Protein Mdm2, p53-binding protein Mdm2, Ubiquitin protein ligase E3 Mdm2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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