Anti-MDM2 Antibody [SMP14] (A281750)

$145

Mouse monoclonal [SMP14] antibody to MDM2 for IHC-P, IHC-Fr, IP and IHC-R.

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-MDM2 Antibody [SMP14]
Description
Mouse monoclonal [SMP14] antibody to MDM2.
Specificity
This antibody recognises the ~90 kDa MDM2 protein, which forms a complex with p53 leading to p53 inhibition.MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.
Applications
IHC-P, IHC-Fr, IP, IHC-R
Dilutions
IHC-P 1: 1:200 - 1:500
Reactivity
Human, Mouse
Immunogen
Synthetic peptide sequence CSRPSTSSRRRAISE corresponding to amino acids 154-167 of human MDM2.
Sequence
CSRPSTSSRRRAISE
Host
Mouse
Clonality
Monoclonal
Clone ID
SMP14
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein A affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti MDM2 antibody, clone SMP14 recognizes the ~90 kDa MDM2 protein, which forms a complex with p53 leading to p53 inhibition.MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.
Synonyms
ACTFS, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Hdm 2, Hdm2, HDMX, MDM 2, MDM2 oncogene E3 ubiquitin protein ligase, Mdm2 p53 E3 ubiquitin protein ligase homolog, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, MDM2BP, MDM2_HUMAN, Mouse Double Minute 2, MTBP, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, p53 Binding Protein Mdm2, p53-binding protein Mdm2, Ubiquitin protein ligase E3 Mdm2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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