Recombinant Anti-Melanoma Antibody [MLANA/8365R] (A315299)

Anti-Melanoma Antibody [MLANA/8365R]

Recombinant rabbit monoclonal [MLANA/8365R] antibody to Melanoma.

This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

Human skin or melanoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment corresponding to the N-terminus of human Melan A protein.

Rabbit

Monoclonal

MLANA/8365R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

20-22 kDa (doublet)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Antigen LB39 AA, Antigen SK29 AA, MART1, melan A, Melan A protein, Melanoma antigen recognized by T-cells 1 , Monophenol monooxygenase, Tumor rejection antigen AB, tyrosinase