Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575)

Name: Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free
Brand: Antibodies.com
SKU: A323575
Price: 295.0 USD
Availability: InStock

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$295

Recombinant humanized monoclonal antibody to IL-5 for ELISA, FACS, Functional Assay and In Vivo.

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Delivery

Freight Charges

$40 to United States

Lead Time

7-10 Business Days

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Telephone

+1 (314) 370-6046

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Recombinant Antibody

Specifications

Name

Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free

Description

Recombinant humanized monoclonal antibody to IL-5.

Applications

ELISA, FACS, Functional Assay, In Vivo

Reactivity

Human

Host

Humanized

Clonality

Monoclonal

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A affinity chromatography.

Concentration

Reconstitution dependent.

Molecular Weight

This antibody has a predicted MW of 146.24 kDa.

Purity

> 95% (by SDS-PAGE and SEC-HPLC).

Product Form

Lyophilized

Reconstitution

Reconstitute with 100µl of sterile double-distilled water to bring antibody to 1mg/ml concentration. Gently shake to solubilize completely. Do not vortex!

Formulation

Lyophilized from 25mM Histadine, pH 6.2, with 8% Sucrose and 0.01% Tween80.

Storage

Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.

Synonyms

B cell differentiation factor I, B-cell differentiation factor I, Colony stimulating factor, Colony stimulating factor eosinophil, EDF , Eosinophil differentiation factor, IL 5, IL5, IL5_HUMAN, Interleukin 5, Interleukin 5 (colony stimulating factor eosinophil), Interleukin 5 (colony stimulating factor, eosinophil), Interleukin-5, Interleukin5, T cell replacing factor, T-cell replacing factor, TRF

Suitable Secondaries

See all Anti-Human IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (5)

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Figure 1: SDS-PAGE - Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575)

SDS-PAGE analysis of Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575) under reducing (R) conditions confirms that the purity of this antibody is greater than 95%.

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Figure 2: Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575)

SEC-HPLC analysis of Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575) confirms that the purity of this antibody is 98.47%.

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Figure 3: Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575)

Immobilized recombinant human IL-5 protein (His tag) at 2 µg/ml is bound by Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575). EC₅₀ = 0.1188 µg/ml.

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Figure 4: Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575)

Mepolizumab Biosimilar - Anti-IL-5 Antibody - Low endotoxin, Azide free (A323575) induced FACS blocking was evaluated using Human IL-5Rß-FL/HIL-5Ra CHOS. The IC50 was approximately 2.844 µg/ml.

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