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Anti-MMP-2 (L638) Antibody

Total Citations (59)
Rabbit polyclonal antibody to MMP-2 (L638) from Bioworld Technology (BS1236).
Name: Anti-MMP-2 (L638) Antibody
Description: Rabbit polyclonal antibody to MMP-2 (L638)
Specificity: MMP-2 (L638) pAb detects endogenous levels of MMP-2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 601-650 of Human MMP-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 74 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
Tissue Specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
Involvement in Disease: Multicentric osteolysis, nodulosis, and arthropathy: An autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy.
Sequence Similarities: Belongs to the peptidase M10A family.
Post-Translational Modification: Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
Cellular Location: Secreted > Extracellular space > Extracellular matrix. Membrane. Nucleus.

Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
UniProt: P08253
Synonyms: 72 kDa gelatinase Antibody
72kD type IV collagenase Antibody
CLG 4 Antibody
CLG 4A Antibody
CLG4 Antibody
CLG4A Antibody
Collagenase Type 4 alpha Antibody
Collagenase type IV A Antibody
Gelatinase A Antibody
Gelatinase alpha Antibody
Gelatinase neutrophil Antibody
Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase Antibody
Matrix Metalloproteinase 2 Antibody
Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Antibody
Matrix metalloproteinase II Antibody
Matrix metalloproteinase-2 Antibody
MMP 2 Antibody
MMP II Antibody
MMP2 Antibody
MMP2_HUMAN Antibody
MONA Antibody
Neutrophil gelatinase Antibody
PEX Antibody
TBE 1 Antibody
TBE-1 Antibody
Information: Target information shown above is from the UniProt Consortium.
For details please refer to datasheet.
For details please refer to datasheet.
For details please refer to datasheet.
For details please refer to datasheet.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.

Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. Int. Immunopharmacol. (2016) Apr 30 36 : 158-164

Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression. Cell Biochem. Funct. (2016) Apr 34 3: 133-41

(-)--hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity. Oncol. Rep. (2016) Apr 35 4: 2246-56

Knocking down Dp71 expression in A549 cells reduces its malignancy in vivo and in vitro. Cancer Invest. (2016) 34 1: 16-25

Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. Oxid Med Cell Longev (2016) 2016 : 6815727

Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells. Am J Transl Res (2015) 7 9: 1660-74

Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles. Exp. Gerontol. (2015) Dec 72 : 261-8

Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis. Acta Biomater (2016) Jan 29 : 398-408

Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway. Int. J. Biochem. Cell Biol. (2015) Dec 69 : 173-82

Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer. Oncotarget (2015) Oct 20 6 32: 33470-85

Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells. Mol. Cell. Biochem. (2015) Dec 410 1-2: 143-54

Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF- signaling. Cancer Lett. (2015) Nov 1 368 1: 105-14

Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway. Acta Biochim. Biophys. Sin. (Shanghai) (2015) Jul 47 7: 539-47

Angiotensin II Induces an Increase in Matrix Metalloproteinase 2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic Aneurysms Through JNK, ERK1/2, and p38 MAPK Activation. J. Cardiovasc. Pharmacol. (2015) Sep 66 3: 285-93

Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells. Int. J. Oncol. (2015) 46 6: 2355-63

Angiotensin II increases matrix metalloproteinase 2 expression in human aortic smooth muscle cells via AT1R and ERK1/2. Exp. Biol. Med. (Maywood) (2015) Dec 240 12: 1564-71

Overexpression of HMGB3 protein promotes cell proliferation, migration and is associated with poor prognosis in urinary bladder cancer patients. Tumour Biol. (2015) Jun 36 6: 4785-92

SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression. Cell. Physiol. Biochem. (2015) 35 3: 875-84

Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma. Biochem. Biophys. Res. Commun. (2015) Mar 6 458 2: 234-9

Stromal-derived factor-1/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer. Oncotarget (2015) Mar 10 6 7: 4717-32

Epigenetic changes and functional study of HOXA11 in human gastric cancer. Epigenomics (2015) 7 2: 201-13

Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. J Drug Target (2015) Apr 23 3: 266-74

Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells. Cancer Chemother. Pharmacol. (2015) Feb 75 2: 353-63

DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling. Am J Cancer Res (2014) 4 6: 710-24

Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo. Int. J. Oncol. (2014) Dec 45 6: 2355-64

Effect of exercise training of different intensities on anti-inflammatory reaction in streptozotocin-induced diabetic rats. Biol Sport (2014) Mar 31 1: 73-9

Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells. Oncol. Rep. (2014) Oct 32 4: 1741-7

Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF- signalling. J. Cell. Mol. Med. (2014) Dec 18 12: 2499-511

Sophoricoside fails the embryo implantation by compromising the uterine endometrial receptivity at implantation ""window"" of pregnant mice. Chem. Biol. Interact. (2014) Aug 5 219 : 57-63

Metformin rescues the MG63 osteoblasts against the effect of high glucose on proliferation. J Diabetes Res (2014) 2014 : 453940

Poloxamer-188 can attenuate blood-brain barrier damage to exert neuroprotective effect in mice intracerebral hemorrhage model. J. Mol. Neurosci. (2015) Jan 55 1: 240-50

Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway. Exp. Mol. Pathol. (2014) Jun 96 3: 411-21

Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis. Clin. Exp. Immunol. (2014) Sep 177 3: 586-97

Granulocyte/macrophage colony-stimulating factor influences angiogenesis by regulating the coordinated expression of VEGF and the Ang/Tie system. PLoS ONE (2014) 9 3: e92691

Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway. Diabetes Obes Metab (2014) Sep 16 9: 850-60

Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway. Anticancer Drugs (2014) Aug 25 7: 778-89

Icaritin suppresses the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression. Acta Pharmacol. Sin. (2014) Apr 35 4: 531-9

Inhibition of metastatic tumor growth and metastasis via targeting metastatic breast cancer by chlorotoxin-modified liposomes. Mol. Pharm. (2014) Oct 6 11 10: 3233-41

IDH1 overexpression induced chemotherapy resistance and IDH1 mutation enhanced chemotherapy sensitivity in Glioma cells in vitro and in vivo. Asian Pac. J. Cancer Prev. (2014) 15 1: 427-32

Abnormal expression of CDK11p58 in prostate cancer. Cancer Cell Int. (2014) 14 1: 2

MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4. Br. J. Cancer (2014) Jan 21 110 2: 450-8

Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion. Discov Med (2013) Oct 16 88: 137-47

Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. J. Biol. Chem. (2013) Sep 27 288 39: 28021-33

CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity. Reprod. Biol. Endocrinol. (2013) 11 : 64

Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model. Biomaterials (2013) Sep 34 28: 6871-81

Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition. Exp. Cell Res. (2013) Aug 1 319 13: 2058-72

A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells. Cell Tissue Res. (2013) Sep 353 3: 409-23

Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy. Cardiovasc Diabetol (2013) 12 : 50

Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. PLoS ONE (2013) 8 3: e59002

The antioxidant property of pachymic acid improves bone disturbance against AH plus-induced inflammation in MC-3T3 E1 cells. J Endod (2013) Apr 39 4: 461-6

Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats. World J. Gastroenterol. (2012) Dec 21 18 47: 7063-9

Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice. J. Hazard. Mater. (2012) Nov 30 241-242 : 231-40

Effect of Etiasa on the expression of matrix metalloproteinase-2 and tumor necrosis factor- in a rat model of ulcerative colitis. Mol Med Rep (2012) Nov 6 5: 996-1000

Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg. Med. Chem. (2012) Jul 1 20 13: 4164-71

Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells. Int. J. Biochem. Cell Biol. (2012) Jun 44 6: 998-1008

Methylation of TFPI-2 is an early event of esophageal carcinogenesis. Epigenomics (2012) Apr 4 2: 135-46

MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in a p-ERK-dependent manner in castration-resistant prostate cancer. Prostate (2012) Aug 1 72 11: 1171-8

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. (2012) Apr 1 317 1: 24-32

Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Exp. Biol. Med. (Maywood) (2011) May 1 236 5: 592-7

Description: Rabbit polyclonal antibody to MMP-2
Application: WB, IHC, IF, ELISA
Host: Rabbit
Reactivity: Human, Mouse, Rat, Monkey
Immunogen: Synthesized peptide derived from the C-terminal region of human MMP-2.

£180 – £234

Description: Rabbit polyclonal antibody to MMP-2
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human MMP-2.

£180 – £234

Description: Rabbit polyclonal antibody to MMP-2.
Application: WB, IP
Host: Rabbit
Isotype: IgG
Reactivity: Rat


Description: Rabbit polyclonal antibody to MMP-2.
Application: WB
Host: Rabbit
Isotype: IgG
Reactivity: Human

£134 – £256

Please Note: Anti-MMP-2 (L638) Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | BS1236
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100µl £283

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