Anti-MMP2 Antibody [4D3] (A315327)

Anti-MMP2 Antibody [4D3]

Mouse monoclonal [4D3] antibody to MMP2.

It recognizes a protein of 72kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

U-138 MG or U-87 MG cells. Human placenta or colon carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant human MMP2 protein fragment (aa557-569).

Mouse

Monoclonal

4D3

IgG1

Protein A/G chromatography.

200 µg/ml

72 kDa (Pro) / 63 kDa (cleaved)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

72 kDa gelatinase, 72 kDa type IV collagenase, 72kD type IV collagenase, CLG 4, CLG 4A , CLG4, CLG4A, Collagenase Type 4 alpha, Collagenase type IV A, EC 3.4.24.24, Gelatinase A, Gelatinase alpha , Gelatinase neutrophil , Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase, Matrix metalloproteinase 2, Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase), Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metalloproteinase II, Matrix metalloproteinase-2, MMP 2, MMP II, MMP-2, MMP2_HUMAN, MONA, Neutrophil gelatinase, PEX, TBE 1, TBE-1