Anti-MRP3 Antibody [ABCC3/2971] (A250438)

Anti-MRP3 Antibody [ABCC3/2971]

Mouse monoclonal [ABCC3/2971] antibody to MRP3.

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps exp- ressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also medi- ates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 815-957, of human MRP3 protein. The exact sequence is proprietary.

Mouse

Monoclonal

ABCC3/2971

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

169 kDa / 137 kDa / 55 kDa / 32 kDa / 65 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MRP3 Antibody [ABCC3/2971] - BSA and Azide free (A253618).

ABC 31, ABC31, ABCC 3, ABCC3, ATP binding cassette sub family C (CFTR/MRP) member 3, ATP binding cassette sub family C member 3, ATP-binding cassette sub-family C member 3, Canalicular multispecific organic anion transporter 2, Canicular multispecific organic anion transporter, CMOAT 2, CMOAT2, EST90757, MLP 2, MLP2, MOAT D, MOAT-D, MOATD, MRP 3, MRP3_HUMAN, Multi specific organic anion transporter D, Multi-specific organic anion transporter D, Multidrug resistance associated protein, Multidrug resistance associated protein 3, Multidrug resistance-associated protein 3, Multispecific organic anion tranporter D