Anti-MSH6 Antibody [MSH6/3091] (A248780)

Mouse monoclonal [MSH6/3091] antibody to MSH6 for ELISA, IF, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-MSH6 Antibody [MSH6/3091]
Description
Mouse monoclonal [MSH6/3091] antibody to MSH6.
Specificity
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Applications
ELISA, IF, WB, IHC-P
Dilutions
IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 374-540, of human MSH6 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
MSH6/3091
Isotype
IgG2b
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
163 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MSH6 Antibody [MSH6/3091] - BSA and Azide free (A251960).
Synonyms
DNA mismatch repair protein Msh6, G/T mismatch binding protein, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC 5, HNPCC5, HSAP, MSH 6, MSH6_HUMAN, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, mutS homolog 6, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit, p160, Sperm associated protein
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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