Anti-MTAP Antibody [MTAP/1813] (A249388)

Mouse monoclonal [MTAP/1813] antibody to MTAP for ELISA, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-MTAP Antibody [MTAP/1813]
Description
Mouse monoclonal [MTAP/1813] antibody to MTAP.
Specificity
This antibody recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Applications
ELISA, WB, IHC-P
Dilutions
WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 97-196, of human MTAP protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
MTAP/1813
Isotype
IgG2b
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
31 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MTAP Antibody [MTAP/1813] - BSA and Azide free (A252568).
Synonyms
5' methylthioadenosine phosphorylase, 5''-methylthioadenosine phosphorylase, BDMF, c86fus, DMSFH, DMSMFH, Epididymis luminal protein 249, HEL 249, LGMBF, MeSAdo phosphorylase, Methylthioadenosine phosphorylase, MSAP, MTA phosphorylase, MTAPase, MTAP_HUMAN, S methyl 5 thioadenosine phosphorylase, S methyl 5' thioadenosine phosphorylase, S-methyl-5''-thioadenosine phosphorylase
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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