Anti-MTF1 Antibody [MTF1/2649] (A249391)

Anti-MTF1 Antibody [MTF1/2649]

Mouse monoclonal [MTF1/2649] antibody to MTF1.

The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human MTF1 protein.

Mouse

Monoclonal

MTF1/2649

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

70 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MTF1 Antibody [MTF1/2649] - BSA and Azide free (A252571).

Metal regulatory transcription factor 1, Metal response element binding transcription factor 1, Metal responsive transcription factor 1, MRE binding transcription factor, MRE-binding transcription factor, MRE-binding transcription factor 1, MTF 1, MTF1_HUMAN, Transcription factor MTF-1, Transcription factor MTF1, Zinc regulatory factor, ZRF