Anti-NeuroG3 Antibody [PCRP-NEUROG3-1E10] - BSA and Azide free (A278318)

Mouse monoclonal [PCRP-NEUROG3-1E10] antibody to NeuroG3 for ELISA, IP and Flow Cytometry.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-NeuroG3 Antibody [PCRP-NEUROG3-1E10] - BSA and Azide free
Description
Mouse monoclonal [PCRP-NEUROG3-1E10] antibody to NeuroG3.
Specificity
This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1.The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.
Applications
ELISA, IP, Flow Cytometry
Dilutions
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells
Reactivity
Human
Immunogen
Recombinant full-length human NeuroG3 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-NEUROG3-1E10
Isotype
IgG2b
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
23.54 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-NeuroG3 Antibody [PCRP-NEUROG3-1E10] (A277730).
Synonyms
ATH4B, Atoh5, bHLHa7, Class A basic helix-loop-helix protein 7, Math4B, Neurogenin-3, Neurogenin3, NGN-3, ngn3, NGN3_HUMAN, OTTHUMP00000019730, Protein atonal homolog 5
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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