Recombinant Anti-PMS2 Antibody [PMS2/8224R] (A315520)

$765

Recombinant rabbit monoclonal [PMS2/8224R] antibody to PMS2 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-PMS2 Antibody [PMS2/8224R]
Description
Recombinant rabbit monoclonal [PMS2/8224R] antibody to PMS2.
Specificity
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS); also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.
Applications
IHC-P
Positive Control
Human colon carcinoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 1-200) of human PMS2 protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
PMS2/8224R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
96 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
DNA mismatch repair gene homologue, DNA mismatch repair protein PMS2, HNPCC4, H_DJ0042M02.9, Mismatch repair endonuclease PMS2, Mismatch repair gene PMSL2, MLH4, PMS 2, PMS1 homolog 2 mismatch repair system, PMS1 protein homolog 2, PMS2 postmeiotic segregation increased 2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae), PMS2CL, PMS2_HUMAN, PMSL2, Postmeiotic segregation increased, S. cerevisiae, 2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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