The basal lamina is a thin (20-200nm), specialized extracellular matrix that plays a crucial role in various biological processes, particularly in providing structural support and signalling to cells. It is composed of a complex network of proteins, including laminins, collagen IV, nidogens, and perlecan, which form a mesh-like structure. Laminins are the major component of the basal lamina and are responsible for its structural integrity. Collagen IV in contrast provides tensile strength, whilst nidogens and perlecan contribute to the stability of the basal lamina. This composition gives the basal lamina its characteristic resilience and flexibility, allowing it to withstand mechanical stress and maintain its structural integrity. A key feature of the basal lamina is its selective permeability. The basal lamina acts as a molecular filter, regulating the passage of molecules between different tissue compartments. This property is essential for maintaining tissue homeostasis by regulating the movement of nutrients, metabolites, and signalling molecules. The basal lamina achieves this through its composition and structure. The arrangement of collagen IV and other macromolecules creates a mesh with specific pore sizes, limiting the diffusion of larger molecules, whilst allowing the passage of smaller ones. This selective permeability enables the basal lamina to modulate the exchange of molecules between adjacent tissues. The basal lamina also plays a vital role in cell adhesion and migration by providing attachment sites for cells, facilitating their adhesion to the extracellular matrix. The presence of cell surface integrin receptors allows cells to bind to specific proteins in the basal lamina, particularly laminins and collagen IV. This interaction promotes cell anchorage and stability, enabling cells to withstand mechanical forces and maintain their position within tissues. Additionally, the basal lamina acts as a scaffold for cell migration during development, tissue repair, and regeneration. Cells can move along the basal lamina, guided by specific signals and cues present within its structure. Finally, the basal lamina serves as a signalling platform for cells. It contains within its structure various growth factors, cytokines, and other signalling molecules that can regulate cell behaviour and tissue homeostasis. These molecules can be stored within the basal lamina or bound to its components, allowing for controlled release and local signalling. The interaction between cells and the basal lamina triggers signalling cascades, influencing cell proliferation, differentiation, and survival. The basal lamina also acts to modulate the stability of growth factors, serving to protect them from degradation and providing cells with a localized source of signalling molecules. We provide a wide product catalogue of research tools for studying basal lamina, including Collagen IV antibodies, 67kDa Laminin Receptor antibodies, Laminin antibodies, Laminin gamma 1 antibodies, and Laminin ELISA Kits. Explore our full basal lamina product range below and discover more, for less.