Recombinant Anti-Progesterone Receptor Antibody [PGR/8099R] (A315532)

$765

Recombinant rabbit monoclonal [PGR/8099R] antibody to Progesterone Receptor for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Progesterone Receptor Antibody [PGR/8099R]
Description
Recombinant rabbit monoclonal [PGR/8099R] antibody to Progesterone Receptor.
Specificity
Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.
Applications
IHC-P
Positive Control
Human breast carcinoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 1-200) of human PGR. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
PGR/8099R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
PR-A (81 kDa) / PR-B (116 kDa).
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, PRGR_HUMAN, Progestin receptor form A, Progestin receptor form B
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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