Rat monoclonal (KT81) antibody to RAB11B from Absea Biotechnology (061009H03).
|Description:||Rat monoclonal (KT81) antibody to RAB11B.|
|Immunogen:||Recombinant mouse RAB11B.|
|Amino Acid Start:||177|
|Amino Acid End:||420|
|Purification:||Antibody is purified from culture supernatant using a protein G column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.|
|Tissue Specificity:||Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets.|
|Sequence Similarities:||Belongs to the small GTPase superfamily. Rab family.|
|Post-Translational Modification:||Citrullinated by PADI4.|
|Cellular Location:||Recycling endosome membrane. Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cytoplasmic vesicle > Phagosome membrane.
Recruited to phagosomes containing S.aureus.
|Synonyms:||GTP binding protein YPT3 Antibody
GTP-binding protein ypt3 Antibody
H YPT3 Antibody
RAB 11A Antibody
RAB11B member RAS oncogene family Antibody
RAB11B, member of RAS oncogene family Antibody
Ras related protein Rab 11B Antibody
RAS-associated protein RAB11B Antibody
Ras-related protein Rab-11B Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-RAB11B Antibody is for research use only. It is not intended for diagnostic of therapeutic use.