Anti-Retinol Binding Protein Antibody [SPM442] (A249838)

Anti-Retinol Binding Protein Antibody [SPM442]

Mouse monoclonal [SPM442] antibody to Retinol Binding Protein.

This antibody recognizes a protein of 21kDa-25kDa, identified as retinol binding protein (RBP). Its epitope localizes between aa 74-182 of human RBP. This antibody recognizes reduced and carboxy-methylated RBP (RCM-RBP) as well as the circulatory RBP but not the native RBP, thereby suggesting that its epitope becomes accessible either on unfolding or upon binding of RBP to transthyretin (prealbumin). RBP is responsible for distributing retinol from the retinoid stores in the liver to the various target tissues. Once secreted into the blood with bound retinol, the vitamin carrier circulates complexed with transthyretin prior to vitamin delivery at the plasma membrane through a receptor-mediated mechanism.

IF, WB, IHC-P

IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Monkey, Goat, Rabbit, Rat, Mouse

Native Retinol Binding Protein purified from human plasma.

Mouse

Monoclonal

SPM442

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

21-25 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Retinol Binding Protein Antibody [SPM442] - BSA and Azide free (A253018).