Anti-SDHA Antibody [SDHA/7491] (A315627)

$765

Mouse monoclonal [SDHA/7491] antibody to SDHA for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-SDHA Antibody [SDHA/7491]
Description
Mouse monoclonal [SDHA/7491] antibody to SDHA.
Specificity
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Applications
IHC-P
Positive Control
Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 450-650) of human SDHA protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
SDHA/7491
Isotype
IgG2
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
70 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
CMD1GG, DHSA_HUMAN, Flavoprotein subunit of complex II, Fp, PGL5, SDH 2, SDH1, SDH2, SDHF, Succinate dehydrogenase complex flavoprotein subunit, Succinate dehydrogenase complex flavoprotein subunit A, Succinate dehydrogenase complex flavoprotein subunit precursor, Succinate dehydrogenase complex subunit A, Succinate dehydrogenase complex subunit A flavoprotein, Succinate dehydrogenase complex subunit A flavoprotein (Fp), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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