Rat monoclonal (KT74) antibody to SMC2 from Absea Biotechnology (160404G04).
|Description:||Rat monoclonal (KT74) antibody to SMC2.|
|Immunogen:||Recombinant mouse SMC2 (aa167 - aa409).|
|Amino Acid Start:||177|
|Amino Acid End:||420|
|Purification:||Antibody is purified from culture supernatant using a protein G column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).|
|Sequence Similarities:||Belongs to the SMC family. SMC2 subfamily.|
|Cellular Location:||Nucleus. Cytoplasm. Chromosome.
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity).
|Synonyms:||CAP E Antibody
Chromosome associated protein E Antibody
Chromosome-associated protein E Antibody
hCAP E Antibody
SMC 2 Antibody
SMC protein 2 Antibody
SMC2 L1 Antibody
Structural maintenance of chromosomes (SMC) family member chromosome associated protein E Antibody
Structural maintenance of chromosomes 2 Antibody
Structural maintenance of chromosomes 2 like 1 Antibody
Structural maintenance of chromosomes 2 yeast like 1 Antibody
Structural maintenance of chromosomes protein 2 Antibody
XCAP E homolog Antibody
XCAP-E homolog Antibody
XCAPE homolog Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-SMC2 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.