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Anti-SNAI1 Antibody

Rabbit polyclonal antibody to SNAI1 from ABclonal (A5243).
Name: Anti-SNAI1 Antibody
Description: Rabbit polyclonal antibody to SNAI1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide of human SNAI1.
Protein Length: 264
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Tissue Specificity: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Sequence Similarities: Belongs to the snail C2H2-type zinc-finger protein family.
Post-Translational Modification: Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction of EMT and cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level.
Cellular Location: Nucleus. Cytoplasm.

Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
UniProt: O95863
Gene ID: 6615
Synonyms: dJ710H13.1 Antibody
Protein sna Antibody
Protein snail homolog Antibody
Protein snail homolog 1 Antibody
SLUGH2 Antibody
SNA Antibody
Sna protein Antibody
SNAH Antibody
SNAI Antibody
SNAI1_HUMAN Antibody
SNAIL Antibody
Snail 1 homolog Antibody
Snail 1 zinc finger protein Antibody
Snail homolog 1 (Drosophila) Antibody
SNAIL, Drosophila, homolog of, 1 Antibody
SNAIL1 Antibody
Zinc finger protein SNAI1 Antibody
Information: Target information shown above is from the UniProt Consortium.
Immunohistochemistry - Anti-SNAI1 Antibody from ABclonal (A5243) - Antibodies.com
Immunohistochemistry of paraffin-embedded human colon carcinoma using SNAI1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry - Anti-SNAI1 Antibody from ABclonal (A5243) - Antibodies.com
Immunohistochemistry of paraffin-embedded human esophagus using SNAI1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry - Anti-SNAI1 Antibody from ABclonal (A5243) - Antibodies.com
Immunohistochemistry of paraffin-embedded human gastric cancer using SNAI1 antibody at dilution of 1:100 (x40 lens).
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (1)
Description: Goat polyclonal antibody to SNAI1.
Application: ELISA, WB, IHC
Host: Goat
Isotype: IgG
Reactivity: Human, Rat

£205

Description: Rabbit polyclonal antibody to SNAI1 (Phospho-Ser246)
Application: WB, IF
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.

£180 – £234

Description: Rabbit polyclonal antibody to SNAI1
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Full length fusion protein

£234

Description: Rabbit polyclonal antibody to SNAI1 (Ab-246)
Application: WB
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized non-phosphopeptide derived from human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M).

£180 – £234

Please Note: Anti-SNAI1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A5243
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £35 to Europe