Anti-TDP43 Antibody [TARDP/349] (A315714)

Anti-TDP43 Antibody [TARDP/349]

Mouse monoclonal [TARDP/349] antibody to TDP43.

TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

ELISA, WB, IHC-P

Human cerebrum or colon.

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant fragment within human TDP43 aa 200 to the C-terminus.

Mouse

Monoclonal

TARDP/349

Unconjugated

Protein A/G chromatography.

200 µg/ml

44 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ALS10, OTTHUMP00000002171, OTTHUMP00000002172, OTTHUMP00000002173, TADBP_HUMAN, TAR DNA binding protein, TAR DNA binding protein 43, TAR DNA-binding protein 43, TARDBP, TDP 43, TDP-43