Anti-TNF Receptor I Antibody [HM104] (PE) (A280612)

Anti-TNF Receptor I Antibody [HM104] (PE)

Rat monoclonal [HM104] antibody to TNF Receptor I (PE).

This antibody recognises an extracellular region of mouse CD120a, also known as TNF receptor type I (TNFR1). TNFR1 is an ubiquitously expressed transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily, which plays a key role in regulating the inflammatory response, acting as a receptor for tumor necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (TNF-beta). CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumor necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor.

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Mouse

Rat

Monoclonal

HM104

IgG2a

Ion exchange chromatography of ascites.

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Rat anti Mouse CD120a antibody, clone HM104 recognizes an extracellular region of mouse CD120a, also known as TNF receptor type I (TNFR1). TNFR1 is an ubiquitously expressed transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily, which plays a key role in regulating the inflammatory response, acting as a receptor for tumor necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (TNF-beta). CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumor necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor.

CD120a, FPF, MGC19588, p55, p55-R, p60, TBP1, TBPI, TNF R, TNF R55, TNF-R1, TNF-RI, TNFAR, TNFR-I, TNFR1, TNFR55, TNFR60, TNFRI, TNFRSF1a, TNR1A_HUMAN, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily, member 1A, Tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, Tumor necrosis factor-binding protein 1

This product is for research use only. It is not intended for diagnostic or therapeutic use.