This antibody recognises Toll-interacting protein (TOLLIP), an ubiquitin binding protein that plays an important role in regulating the innate immune response.TOLLIP, as the name implies, interacts with a number of Toll-like receptors thereby mediating the regulation of the autophagic clearance and NF-kappaB pathways. The latter pathway, TOLLIP mainly regulates through controlling phosphorylation levels of the IRAK1 kinase. TOLLIP deficiencies have been implicated in increased tuberculosis susceptibility.
Applications
WB, IP
Dilutions
WB: 5 µg/ml
Reactivity
Mouse, Human
Immunogen
Recombinant mouse TOLLIP.
Host
Rat
Clonality
Monoclonal
Clone ID
Kimmy-1
Isotype
IgG2a
Conjugate
Unconjugated
Concentration
1 mg/ml
Molecular Weight
Approximately 30 kDa by Western Blot.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rat anti TOLLIP antibody clone Kimmy-1 recognizes Toll-interacting protein (TOLLIP), an ubiquitin binding protein that plays an important role in regulating the innate immune response.TOLLIP, as the name implies, interacts with a number of Toll-like receptors thereby mediating the regulation of the autophagic clearance and NF-kappaB pathways. The latter pathway, TOLLIP mainly regulates through controlling phosphorylation levels of the IRAK1 kinase. TOLLIP deficiencies have been implicated in increased tuberculosis susceptibility (Sha et al. 2012).
Synonyms
Adapter protein, FLJ33531, IL 1RAcPIP, IL1RAcPIP, TOLIP, TOLIP_HUMAN, Toll interacting protein, Toll-interacting protein
