Anti-TTF1 Antibody [8G7G3/1] (A250139)

Anti-TTF1 Antibody [8G7G3/1]

Mouse monoclonal [8G7G3/1] antibody to TTF1.

This antibody recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse, Rat

Recombinant full-length rat TTF-1 protein.

Mouse

Monoclonal

8G7G3/1

IgG1

kappa

Unconjugated

200 µg/ml

40 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TTF1 Antibody [8G7G3/1] - BSA and Azide free (A253319).

AV026640, BCH, Benign chorea, BHC, Homeobox protein NK 2 homolog A, Homeobox protein NK-2 homolog A, Homeobox protein Nkx 2.1, Homeobox protein Nkx-2.1, Homeobox protein Nkx2.1, NK 2, NK 2 homolog A, NK2, NK2 homeobox 1, NK2, drosophila, homolog of, A, NK2.1, mouse, homolog of, Nkx 2 1, NKX 2.1, NKX 2A, NKX2 1, Nkx2-1, NKX2.1, NKX21_HUMAN, NKX2A, T EBP, T/EBP, TEBP, Thyroid nuclear factor, Thyroid nuclear factor 1, Thyroid specific enhancer binding protein, Thyroid transcription factor 1, Tin man, Tinman, TITF 1, TITF1, TTF 1, TTF-1