Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] (A277636)

Name: Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6]
Brand: Antibodies.com
SKU: A277636
Price: 525.0 USD
Availability: InStock

Enlarge Image

$525

Mouse monoclonal [PCRP-ZC3H7A-1D6] antibody to ZC3H7A for ELISA, IP, Flow Cytometry and IF.

100% Guarantee

Price Match Guarantee

Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

Contact Us

Telephone

+1 (314) 370-6046

orders@antibodies.com

Guarantees

100% Quality Guarantee

Price Match Guarantee

Tags:

Monospecific Antibody

Specifications

Name

Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6]

Description

Mouse monoclonal [PCRP-ZC3H7A-1D6] antibody to ZC3H7A.

Specificity

The zinc finger CCCH domain-containing protein 7A (ZC3H7A), also known as ZC3H7, HSPC055 or ZC3HDC7, is a 971 amino acid protein that contains a C3H1-type zinc finger domain, three C3H1-type zinc fingers and three TPR repeats. Belonging to the ZC3H12 family, ZC3H7A localizes to the nucleus. Existing as two alternatively spliced isoforms, ZC3H7A is encoded by a gene located on human chromosome 16p13.13. Chromosome 16 makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of RubinsteinTaybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn s disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.

Applications

ELISA, IP, Flow Cytometry, IF

Dilutions

IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant full-length human ZC3H7A protein.

Host

Mouse

Clonality

Monoclonal

Clone ID

PCRP-ZC3H7A-1D6

Isotype

IgG1

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Molecular Weight

110 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] - BSA and Azide free (A278224).

Synonyms

HSPC055, ZC3H7, ZC3HDC7, Zinc finger CCCH domain containing protein 7A, zinc finger CCCH type containing 7, zinc finger CCCH type containing 7A, zinc finger CCCH type domain containing 7, zinc finger protein AY163807

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (4)

Enlarge Image

Figure 1: Flow Cytometry - Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] (A277636)

Flow cytometric analysis of PFA-fixed HeLa cells using Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).

Enlarge Image

Figure 2: SDS-PAGE - Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] (A277636)

SDS-PAGE analysis of Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

Enlarge Image

Figure 3: Immunofluorescence - Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] (A277636)

Immunofluorescent analysis of PFA-fixed HeLa cells stained with Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] followed by Goat Anti-Mouse IgG (CF® 488) (Green). CF® 640A Phalloidin (Red).

Enlarge Image

Figure 4: Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] (A277636)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Publishing research using Anti-ZC3H7A Antibody [PCRP-ZC3H7A-1D6] (A277636)? Please let us know so that we can list the citation on this page.