Anti-Bax Antibody (A283428)

Anti-Bax Antibody

Rabbit polyclonal antibody to Bax.

This antibody recognises the Bcl-2-associated X protein (BAX) also known as Bcl-2 like protein 4. BAX together with BAK (BCL-2 antagonist or killer), another member of the Bcl-2 family, plays a key role in the intrinsic apoptosis pathway by inducing mitochondrial outer membrane permeabilization (MOMP). This event is aided by BID (BH3-interacting domain death agonist), which activates the two proteins and thereby facilitates the formation of homo- or heterodimers. Often in the literature, MOMP is regarded as the point of no return upon which a cell is committed to undergo apoptosis.

WB: 1:400

Human, Mouse, Rat

A peptide corresponding to the N-terminus of human BAX.

Rabbit

Polyclonal

IgG

Unconjugated

Affinity chromatography.

Approximately 23 kDa when run under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti BAX antibody recognizes the Bcl-2-associated X protein (BAX) also known as Bcl-2 like protein 4. BAX together with BAK (BCL-2 antagonist or killer), another member of the Bcl-2 family, plays a key role in the intrinsic apoptosis pathway by inducing mitochondrial outer membrane permeabilization (MOMP) (Giansanti and Scovassi 2008). This event is aided by BID (BH3-interacting domain death agonist), which activates the two proteins and thereby facilitates the formation of homo- or heterodimers. Often in the literature, MOMP is regarded as the point of no return upon which a cell is committed to undergo apoptosis (Chipuk et al. 2006).

Apoptosis regulator BAX, Bax-protein, BAXA, Baxdelta2G9, Baxdelta2G9omega, Baxdelta2omega, BAX_HUMAN, Bcl-2-like protein 4, BCL2 associated X protein, BCL2 associated X protein omega, BCL2 associated X protein transcript variant delta2, Bcl2-L-4, BCL2L4, membrane isoform alpha