Anti-c-Fos Antibody (A283419)

Anti-c-Fos Antibody

Rabbit polyclonal antibody to c-Fos.

This antibody recognises c-Fos also known as G0/G1 switch regulatory protein 7 (G0S7). The c-Fos transcription factor is encoded by the c-Fos proto-oncogene and dimerizes with c-Jun, JDP and ATF family members to form the AP-1 transcription factor. c-Fos plays an essential role in mediating cellular signaling responses after cellular stress. The ability of the c-Fos protein to act as a transcription factor is regulated by phosphorylation on selected sites by the kinases p38, ERK, RSK1 and RSK2. The protein accumulates in the nucleus, where it acts as a transcription factor upon formation of heterodimers with c-Jun. This binding prevents the nuclear export and subsequent proteosomal degradation of c-Fos (Halazonetiset al. 1988).

WB: 1:200

Human, Mouse, Rat

A peptide corresponding to the N-terminus of human c-Fos.

Rabbit

Polyclonal

IgG

Affinity chromatography.

Approximately 55 kDa when run under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti c-Fos antibody recognizes c-Fos also known as G0/G1 switch regulatory protein 7 (G0S7). The c-Fos transcription factor is encoded by the c-Fos proto-oncogene and dimerizes with c-Jun, JDP and ATF family members to form the AP-1 transcription factor (Eferl and Wagner 2003).c-Fos plays an essential role in mediating cellular signaling responses after cellular stress. The ability of the c-Fos protein to act as a transcription factor is regulated by phosphorylation on selected sites by the kinases p38, ERK, RSK1 and RSK2 (Lopez-Bergami et al. 2011). The protein accumulates in the nucleus, where it acts as a transcription factor upon formation of heterodimers with c-Jun. This binding prevents the nuclear export and subsequent proteosomal degradation of c-Fos (Halazonetiset al. 1988).

Cellular oncogene fos, FOS, Fos proto-oncogene, AP-1 transcription factor subunit, G0/G1 switch regulatory protein 7, G0S7, Protein c-Fos, Proto-oncogene c-Fos, Transcription factor AP-1 subunit c-Fos