This antibody recognises aldosterone, a steroid hormone (mineralocorticoid family) produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate the bodies electrolyte and water balance. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It acts directly on the kidney to decrease the rate of sodium-ion excretion (with accompanying retention of water), and to increase the rate of potassium-ion excretion. Sheep anti Aldosterone antibody exhibits negligible reactivity with a range of associated hormones and derivatives.
Applications
ELISA
Dilutions
ELISA: 1:300 - 1:5,000
Reactivity
Species Independent
Immunogen
Aldosterone conjugated to Bovine Serum Albumin.
Host
Sheep
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Purification
Protein G affinity chromatography.
Concentration
5 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Sheep anti Aldosterone antibody recognizes aldosterone, a steroid hormone (mineralocorticoid family) produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate the bodies electrolyte and water balance. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It acts directly on the kidney to decrease the rate of sodium-ion excretion (with accompanying retention of water), and to increase the rate of potassium-ion excretion.Sheep anti Aldosterone antibody exhibits negligible reactivity with a range of associated hormones and derivatives.
