Anti-CD20 Antibody [109-3C2] - BSA and Azide free (A253778)

Anti-CD20 Antibody [109-3C2] - BSA and Azide free

Mouse monoclonal [109-3C2] antibody to CD20.

This antibody recognizes a protein of 30-33kDa, which is identified as CD20 (Workshop V; Code CD20.12. Workshop IV; Code B17). It This antibody recognizes an extracellular domain of CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.

Functional Studies, ELISA

Human

Stimulated human leukocytes.

Mouse

Monoclonal

109-3C2

IgG3

kappa

Protein A/G chromatography.

1 mg/ml

33-37 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Store at 4°C.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD20 Antibody [109-3C2] (A250598).

B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, MS4A1