Recombinant Anti-Estrogen Receptor alpha Antibody [ESR1/7444R] (A314936)

Anti-Estrogen Receptor alpha Antibody [ESR1/7444R]

Recombinant rabbit monoclonal [ESR1/7444R] antibody to Estrogen Receptor alpha.

Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems. Studies have shown ER can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas.

MCF-7 cells. Human breast or endometrial carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 495-595) of human ER alpha protein. The exact sequence is proprietary.

Rabbit

Monoclonal

ESR1/7444R

kappa

Protein A/G chromatography.

200 µg/ml

~67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ER, ER-alpha, ESR, ESR1, Estradiol receptor, Estrogen receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1