Anti-HER2 Antibody [HRB2/258] (CF® 488) (A251127)

Anti-HER2 Antibody [HRB2/258] (CF® 488)

Mouse monoclonal [HRB2/258] antibody to HER2 (CF® 488).

This antibody recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Flow Cytometry, IF

Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100

Human, Rat

Recombinant extracellular domain of human HER-2 protein.

Mouse

Monoclonal

IgG2a

kappa

Protein A/G chromatography.

100 µg/ml

185 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Store at 4-8°C. Antibody is stable for 24 months.

CD340, Metastatic lymph node gene 19 protein, MLN 19, MLN19, NEU, NGL, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2

This product is for research use only. It is not intended for diagnostic or therapeutic use.