Anti-IL-17 Antibody [TC11-8H4] (A281815)

Anti-IL-17 Antibody [TC11-8H4]

Rat anti Mouse Interleukin-17

Rat anti mouse Interleukin 17 antibody, clone TC11-8H4 recognizes mouse Interleukin 17, a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction (Chabaud et al. 2000).Rat anti mouse interleukin-17 antibody has been successfully used for the identification of IL-17 secreting cells in a murine anti-tumor immunity model by ELISPOT analysis (Yu et al. 2013)

Mouse

Recombinant mouse IL-17 expressed in E. coli.

Rat

Monoclonal

IgG1

Affinity chromatography.

500 µg/ml

Liquid

Supplied in Borate Buffered Saline; without preservative.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, Interleukin-17A