Anti-IL-17A Antibody [H06-4H4] (A280533)

Anti-IL-17A Antibody [H06-4H4]

Mouse anti Human Interleukin-17A

Mouse anti Human interleukin-17A, clone H06-4H4, recognizes interleukin-17A (IL-17A) also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8). The IL-17 family consists of six proteins (IL-17A to IL-17F) which function as pro-inflammatory cytokines important in the defense against pathogens (Gurczynski & Moore 2017). This antibody recognizes IL-17A, the most studied member of the IL-17 family. IL-17A is expressed by various cell types including CD4+ and CD8+ T helper cells, neutrophil, natural killer, mast and B cells (Chen & Kolls 2017). It elicits its responses via the IL-17 receptor, IL-17RA. Activation of this receptor leads to the activation of NF-?B and mitogen-activated protein kinase to then drive the transcriptional activation of target genes which play key roles in inflammation. IL-17A can also signal to stabilize mRNA transcripts, again to enhance the production of genes including those encoding cytokines, chemokines, antimicrobial peptides and other inflammatory effectors. (Monin & Gaffen 2018). Uncontrolled IL-17A signaling is associated with immunopathology, autoimmune diseases, and cancer, and blocking activity of IL-17A can be beneficial in some clinical settings (Amatya et al. 2017).The purified Mouse anti Human interleukin-17A antibody, clone H06-4H4 (MCA6242GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-17A antibody, clone F01.1-5D10 (MCA6243B) as the detection antibody.

Human

E. coli derived recombinant human full length interleukin-17A (Gly24-Ala155).

Mouse

Monoclonal

IgG2b

Protein G chromatography.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL17, IL17A, Interleukin-17A