Anti-IL-25 Antibody - BSA and Azide free (A283782)

Anti-IL-25 Antibody - BSA and Azide free

Rabbit polyclonal antibody to IL-25.

This antibody recognises interleukin-25 (IL-25) also known as IL-17E. IL-25 is a member of the IL-17 family of cytokines and is expressed by various immune cells including mast cells, eosinophils, basophils and T helper type 2 cells. It is also expressed in non-hematopoietic cells such as epithelial and endothelial cells. As a pleiotropic cytokine, it stimulates stromal, innate immune and adaptive immune cells to regulate Th2 type inflammation. IL-25 exerts its biological function through its receptor IL-17RB, although there is some evidence that it may also bind to the receptor IL-17RA. Through this interaction, IL-25 is able to induce expression of IL-4, IL-5, IL-13 and TSLP. IL-25 is upregulated in asthmatic conditions and can induce typical eosinophil inflammation and airway hyperresponsiveness. IL-25 levels are also associated with the severity of chronic allergic reactions.

WB, ELISA

ELISA: 0.5 µg/ml - 2.0 µg/ml, WB: 0.1 µg/ml - 0.2 µg/ml

Human

E. coli derived recombinant human interleukin-25.

Rabbit

Polyclonal

IgG

Lyophilized

Reconstitute with 0.1 ml of distilled water.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti Human interleukin-25 antibody, recognizes interleukin-25 (IL-25) also known as IL-17E. IL-25 is a member of the IL-17 family of cytokines and is expressed by various immune cells including mast cells, eosinophils, basophils and T helper type 2 cells. It is also expressed in non-hematopoietic cells such as epithelial and endothelial cells (Yao et al. 2016). As a pleiotropic cytokine, it stimulates stromal, innate immune and adaptive immune cells to regulate Th2 type inflammation (Monin & Gaffen 2018). IL-25 exerts its biological function through its receptor IL-17RB, although there is some evidence that it may also bind to the receptor IL-17RA (Yao et al. 2016). Through this interaction, IL-25 is able to induce expression of IL-4, IL-5, IL-13 and TSLP (McGeachy et al. 2019). IL-25 is upregulated in asthmatic conditions and can induce typical eosinophil inflammation and airway hyperresponsiveness (Yao et al. 2016). IL-25 levels are also associated with the severity of chronic allergic reactions (Monin & Gaffen 2018).

IL-17E, IL17E, IL25, Interleukin-17E, Interleukin-25