This antibody recognises 2'-5'-oligoadenylate synthase 1 (OAS1), also known as E18/E16 and p46/p42 OAS.OAS1 is a member of the OAS family of genes induced by interferons (IFN) and viruses, and appears to play a role in regulation of signaling pathways during viral infection. The antiviral role of OAS1 appears to be attributed to its ability to detect short double stranded RNAs (dsRNAs). In addition to viral infections, OAS proteins have been implicated in autoimmune diseases and cancer. OAS1 can affect cell migration and high OAS1 mRNA expression has been linked to worse prognosis in patients with breast cancer.
Applications
WB
Dilutions
WB: 1 µg/ml - 3 µg/ml
Reactivity
Human
Immunogen
A peptide sequence of C-THEYPHFSHRPST from the internal region (near C terminus) of the protein sequence according to NP_058132.2.
Sequence
C-THEYPHFSHRPST
Host
Goat
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
500 µg/ml
Molecular Weight
Approximately 50 kDa in cell lysates
Product Form
Liquid
Formulation
Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.
Storage
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Goat anti OAS1 antibody recognizes 2'-5'-oligoadenylate synthase 1 (OAS1), also known as E18/E16 and p46/p42 OAS.OAS1 is a member of the OAS family of genes induced by interferons (IFN) and viruses, and appears to play a role in regulation of signaling pathways during viral infection (Lee et al. 2019). The antiviral role of OAS1 appears to be attributed to its ability to detect short double stranded RNAs (dsRNAs) (Schwartz et al. 2020). In addition to viral infections, OAS proteins have been implicated in autoimmune diseases and cancer. OAS1 can affect cell migration and high OAS1 mRNA expression has been linked to worse prognosis in patients with breast cancer (Zhang and Yu 2020).
