This antibody recognises silent mating type information regulation 2 homolog 1 (SIRT1) also known as NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and regulatory protein SIR2 homolog 1.SIRT1 is a member of the sirtuin family of deacetylases that play an important role in regulating gene expression. Due to its function in DNA repair and tumorigenesis, SIRT1 has been identified as a potential therapeutic target for cancer.
Applications
WB
Dilutions
WB: 1:400
Reactivity
Human
Immunogen
A peptide corresponding to the C-terminus of human SIRT1.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Purification
Affinity chromatography.
Concentration
200 µg/ml
Molecular Weight
Approximately 117 kDa when run under reducing conditions
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.
Storage
Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti SIRT1 antibody recognizes silent mating type information regulation 2 homolog 1 (SIRT1) also known as NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and regulatory protein SIR2 homolog 1.SIRT1 is a member of the sirtuin family of deacetylases that play an important role in regulating gene expression (Roth and Chen 2014). Due to its function in DNA repair and tumorigenesis, SIRT1 has been identified as a potential therapeutic target for cancer (Roth and Chen 2014).
Synonyms
hSIR2, hSIRT1, NAD-dependent protein deacetylase sirtuin-1, NAD-dependent protein deacylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, SIR2L1
![Flow Cytometry - Anti-SIRT1 Antibody [PCRP-SIRT1-1E11] (A277616) - Antibodies.com](https://cdn.antibodies.com/image/catalog/277/A277616_1.jpg?profile=product_alternative)
![Flow Cytometry - Anti-SIRT1 Antibody [PCRP-SIRT1-1E11] - BSA and Azide free (A278204) - Antibodies.com](https://cdn.antibodies.com/image/catalog/278/A278204_1.jpg?profile=product_alternative)
