Anti-STAT5a Antibody (A283421)

Anti-STAT5a Antibody

Rabbit polyclonal antibody to STAT5a.

This antibody recognises signal transducer and activator of transcription 5A (STAT5A), a member of the STAT protein family. STAT5A plays an important role in cell growth, survival, differentiation and transformation by transducing signals from cytokine receptors to the nucleus.STAT5A is tyrosine phosphorylated by members of the Janus kinase (JAK) family in response to cytokines and growth factor stimulation. Phosphorylation results in STAT activation and the formation of STAT5 homo- and STAT5/STAT3 heterodimers. STAT dimers translocate from the cytoplasm to the nucleus where they act as transcription factors. Deregulated JAK/STAT signaling has been implicated in a variety of cancers, and STATs can regulate the tumor microenvironment to trigger a shift from cancer inhibition to promotion.

WB: 1:200

Mouse, Human, Rat

A peptide corresponding to the C-terminus of mouse STAT5A.

Rabbit

Polyclonal

IgG

200 µg/ml

Approximately 91 kDa when run under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti STAT5A antibody recognizes signal transducer and activator of transcription 5A (STAT5A), a member of the STAT protein family. STAT5A plays an important role in cell growth, survival, differentiation and transformation by transducing signals from cytokine receptors to the nucleus.STAT5A is tyrosine phosphorylated by members of the Janus kinase (JAK) family in response to cytokines and growth factor stimulation. Phosphorylation results in STAT activation and the formation of STAT5 homo- and STAT5/STAT3 heterodimers. STAT dimers translocate from the cytoplasm to the nucleus where they act as transcription factors. Deregulated JAK/STAT signaling has been implicated in a variety of cancers, and STATs can regulate the tumor microenvironment to trigger a shift from cancer inhibition to promotion.

Signal transducer and activator of transcription 5A, STAT5