Recombinant Anti-ZAP70 Antibody [ZAP70/3921R] (A250349)

Anti-ZAP70 Antibody [ZAP70/3921R]

Recombinant rabbit monoclonal [ZAP70/3921R] antibody to ZAP70.

ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

ELISA, IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 247-382, of human ZAP70 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

ZAP70/3921R

IgG

Protein A/G chromatography.

200 µg/ml

70 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ZAP70 Antibody [ZAP70/3921R] - BSA and Azide free (A253529).

70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70