Anti-ZAP70 Antibody [ZAP70/528 + 2F3.2] - BSA and Azide free (A253523)

Anti-ZAP70 Antibody [ZAP70/528 + 2F3.2] - BSA and Azide free

Mouse monoclonal [ZAP70/528 + 2F3.2] antibody to ZAP70.

ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

IHC-P: 1-2 µg/ml

Human

Clone ZAP70/528: Recombinant full-length human ZAP70 protein. Clone 2F3.2: Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70.

Mouse

Oligoclonal

ZAP70/528 + 2F3.2

IgG2a, kappa + IgG2a, kappa

Protein A/G chromatography.

1 mg/ml

70 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70