Anti-CD45 Antibody [SPM569 + SPM570] (A249810)

Mouse monoclonal [SPM569 + SPM570] antibody to CD45 for Flow Cytometry, IF, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

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Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
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Email
orders@antibodies.com

Highlighted products for Anti-CD45 Antibody

Name
Anti-CD45 Antibody [SPM569 + SPM570]
Description
Mouse monoclonal [SPM569 + SPM570] antibody to CD45.
Specificity
This antibody recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
Applications
Flow Cytometry, IF, WB, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human, Canine
Immunogen
Human B-lymphoma cells and T-lymphoma cells.
Host
Mouse
Clonality
Oligoclonal
Clone ID
SPM569 + SPM570
Isotype
IgG1, kappa + IgG1, kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
180-220 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes

Please note, this product is an oligoclonal antibody; it is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies not only have the specificity and batch-to-batch consistency of a monoclonal antibody, but they also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen.

This oligoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD45 Antibody [SPM569 + SPM570] - BSA and Azide free (A252990).

Synonyms
B220, CD 45, CD45 antigen, CD45R, GP180, L-CA, LCA, Leukocyte common antigen, loc, Ly-5, LY5, Ly5, homolog of, Lyt-4, OTTHUMP00000033813, OTTHUMP00000033816, OTTHUMP00000033817, OTTHUMP00000038574, Protein tyrosine phosphatase receptor type c polypeptide, Protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase, receptor type, C, Protein tyrosine phosphatase, receptor type, c polypeptide, Ptprc, PTPRC_HUMAN, Receptor-type tyrosine-protein phosphatase C, T200, T200 glycoprotein, T200 leukocyte common antigen
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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