Anti-Complement Factor B Antibody [014III-33.2.4.3] (A278895)

Anti-Complement Factor B Antibody [014III-33.2.4.3]

Mouse monoclonal [014III-33.2.4.3] antibody to Complement Factor B.

This antibody recognises the 30 kDa Ba fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. Mouse anti Human Complement Factor B (Ba Fragment) antibody, clone 014III-33.2.4.3 blocks activity of the target protein. Removal of Sodium Azide is recommended prior to use in functional assays.

Flow Cytometry, ELISA, IHC-Fr, WB, Functional Assays

Human

Purified human complement factor b.

Mouse

Monoclonal

014III-33.2.4.3

IgG1

Unconjugated

Lot Specific

Liquid

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human Complement Factor B (Ba Fragment) antibody, clone 014III-33.2.4.3 recognises the 30 kDa Ba fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. Mouse anti Human Complement Factor B (Ba Fragment) antibody, clone 014III-33.2.4.3 blocks activity of the target protein. Removal of Sodium Azide is recommended prior to use in functional assays.

C3/C5 convertase, Glycine-rich beta glycoprotein, PBF2, Properdin factor B