Transcriptional cofactors are essential proteins that modulate gene expression by influencing the activity of transcription factors and RNA polymerase. They play important roles in development, differentiation, and responses to environmental signals. CBP/p300 (CREB-Binding Protein and p300) are transcriptional coactivators interacting with a range of transcription factors. They enhance gene expression by both enzymatically acetylating histones and bridging interactions between transcription factors and the basal transcription machinery. CBP/p300 are involved in processes including cell cycle regulation, DNA repair, apoptosis, and embryonic development. Mutations in CBP/p300 are linked to Rubinstein-Taybi syndrome, a developmental disorder characterized by physical abnormalities and intellectual disabilities. The Mediator complex cofactor acts as a molecular bridge between transcription factors bound to enhancer regions and RNA polymerase II at the promoter and helps in the formation of the transcriptional pre-initiation complex and the regulation of transcriptional initiation. Mediator is essential for the transcription of most protein-coding genes and as such is involved in many cellular processes, including cell differentiation, signal transduction, and responses to stress. Mutations in Mediator subunits have also been associated with developmental disorders and cancer. For example, CDK8 and CDK19 are subunits of the Mediator complex associated with the kinase module. Mutations in these subunits have been implicated in various cancers, including colorectal cancer and acute myeloid leukaemia (AML). NCoR (Nuclear Receptor Corepressor) and SMRT (Silencing Mediator of Retinoid and Thyroid Receptors) are corepressors that interact with nuclear receptors (e.g., thyroid hormone receptor) and other transcription factors. They recruit histone deacetylases (HDACs) to repress gene expression by deacetylating histones. These corepressors are involved in regulating genes related to metabolism, development, and immunity. They play roles in maintaining homeostasis by suppressing gene expression in the absence of specific signalling ligands. Dysregulation of NCoR and SMRT are associated with metabolic disorders and cancer. For example, when NCoR and SMRT are unable to effectively repress the transcriptional activity of nuclear receptors like PPARγ (peroxisome proliferator-activated receptor gamma), it can lead to insulin resistance and impaired glucose metabolism. SRC-1 (Steroid Receptor Coactivator-1) is a coactivator that interacts with nuclear hormone receptors like estrogen receptor and androgen receptor. It enhances gene expression by recruiting histone acetyltransferases (HATs) and other transcriptional machinery. SRC-1 is therefore involved in hormone-dependent gene regulation, cell proliferation, and differentiation and its overexpression plays roles in breast and prostate cancer by modulating the activity of hormone receptors. The SWI/SNF complex is a chromatin remodelling complex that facilitates access to DNA by sliding or ejecting nucleosomes, allowing transcription factors and RNA polymerase to bind to DNA more effectively. SWI/SNF is crucial for gene regulation during development, differentiation, and responses to environmental cues. Mutations in SWI/SNF subunits are common in certain cancers. For example, ARID1A is a common target of mutations in ovarian clear cell carcinoma. Loss-of-function mutations in ARID1A can result in altered chromatin structure, leading to aberrant gene expression and contribute to tumour development and progression. Thus, transcriptional cofactors are pivotal in controlling gene expression levels by modulating the activity of transcription factors and the chromatin environment. We offer a large product catalogue of research tools for studying transcriptional cofactors, including Prohibitin antibodies, CtBP1 antibodies, RIP140 antibodies, SIRT7 antibodies, and Prohibitin ELISA Kits. Explore our full transcriptional cofactors product range below and discover more, for less.