Recombinant Anti-TOP1MT Antibody [rTOP1MT/488] (A277880)

Recombinant mouse monoclonal [rTOP1MT/488] antibody to TOP1MT for Flow Cytometry, IF, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-TOP1MT Antibody [rTOP1MT/488]
Description
Recombinant mouse monoclonal [rTOP1MT/488] antibody to TOP1MT.
Specificity
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Applications
Flow Cytometry, IF, WB, IHC-P
Dilutions
Flow Cytometry: 0.5-1 µg/million cells, IF: 0.5-1 µg/ml, WB: 0.5-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human TOP1MT protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
rTOP1MT/488
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
70 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TOP1MT Antibody [rTOP1MT/488] - BSA and Azide free (A278468).
Synonyms
2900052H09Rik, DNA topoisomerase I, DNA topoisomerase I, mitochondrial, mitochondrial, TOP1M_HUMAN, Topoisomerase I mitochondrial
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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