Anti-Transferrin Antibody [TF/4799] - BSA and Azide free (A317133)

$765

Mouse monoclonal [TF/4799] antibody to Transferrin for WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Transferrin Antibody [TF/4799] - BSA and Azide free
Description
Mouse monoclonal [TF/4799] antibody to Transferrin.
Specificity
Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.
Applications
WB, IHC-P
Positive Control
Human liver or hepatocellular carcinoma.
Dilutions
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 311-445) of human TF protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
TF/4799
Isotype
IgG2
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
79 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Apotransferrin, ATRAF, Atransferrinemia, Beta 1 metal binding globulin, Beta-1 metal-binding globulin, DKFZp781D0156, HEL S 71p, HELS71p, PRO1400, PRO1557, PRO2086, Serotransferrin, Serotransferrin precursor, Siderophilin, TF, TFQTL1, Transferin, TRFE_HUMAN
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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