Recombinant Anti-ZAP70 Antibody [rZAP70/2046] (A250347)

Recombinant mouse monoclonal [rZAP70/2046] antibody to ZAP70 for ELISA and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-ZAP70 Antibody [rZAP70/2046]
Description
Recombinant mouse monoclonal [rZAP70/2046] antibody to ZAP70.
Specificity
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Applications
ELISA, IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 247-382, of human ZAP70 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
rZAP70/2046
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
70 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ZAP70 Antibody [rZAP70/2046] - BSA and Azide free (A253527).
Synonyms
70 kDa zeta associated protein, 70 kDa zeta-associated protein, 70 KDa Zeta-Associated Protein2, 70 KDa Zeta-Chain Associated Protein, EC 2.7.10, EC 2.7.10.2, FLJ17670, FLJ17679, Selective T cell defect, SRK, STCD, STD, Syk related tyrosine kinase, Syk-related tyrosine kinase, Truncated ZAP kinase, Tyrosine protein kinase ZAP70, Tyrosine-protein kinase ZAP-70, TZK, ZAP 70, ZAP-70, ZAP70_HUMAN, Zeta chain associated protein kinase 70kD, Zeta chain associated protein kinase 70kDa, Zeta chain associated protein kinase 70kDa isoform 1, Zeta chain associated protein kinase 70kDa isoform 2, Zeta chain of T cell receptor associated protein kinase 70, Zeta chain TCR associated protein kinase 70kD, Zeta chain TCR associated protein kinase 70kDa, Zeta-Chain (TCR) Associated ProteinKinase (70 KD), Zeta-Chain Associated Protein Kinase, 70kD
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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