Anti-AKT1 (phospho Thr450) Antibody (A283548)

$420

Rabbit polyclonal antibody to AKT1 (phospho Thr450) for WB.

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-AKT1 (phospho Thr450) Antibody
Description
Rabbit polyclonal antibody to AKT1 (phospho Thr450).
Specificity
This antibody recognises AKT1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt, when phosphorylated at threonine 450. AKT1 is a 480 amino acid ~48 kDa protein kinase that play a key role in the PI3K-Akt signaling pathway, known to regulate cell growth, proliferation and survival. Phosphorylation of threonine 308 and serine 473 are required for full activation of AKT1. Newly synthesized Akt is suggested to require phosphorylation at threonine 450 for proper protein folding.
Applications
WB
Dilutions
WB: 1:500 - 1:1,000
Reactivity
Human
Immunogen
Phospho-specific peptide corresponding to residues surrounding Thr450 of human AKT1.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate

Unconjugated

Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.
Storage
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti AKT1 (pThr450) antibody recognizes AKT1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt, when phosphorylated at threonine 450. AKT1 is a 480 amino acid ~48 kDa protein kinase that play a key role in the PI3K-Akt signaling pathway, known to regulate cell growth, proliferation and survival. Phosphorylation of threonine 308 and serine 473 are required for full activation of AKT1. Newly synthesized Akt is suggested to require phosphorylation at threonine 450 for proper protein folding (Liao and Hung 2010).
Synonyms
AKT, AKT 1, AKT1_HUMAN, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein kinase B, Protein Kinase B Alpha, Proto-oncogene c-Akt, RAC, RAC Alpha, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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