Anti-TNF alpha Antibody [cA2] (A279979)

Anti-TNF alpha Antibody [cA2]

Human monoclonal [cA2] antibody to TNF alpha.

Human

Human TN alpha.

Human

Monoclonal

cA2

IgG1

Protein A affinity chromatography.

1 mg/ml

>98% (by SDS-PAGE).

Supplied in Phosphate Buffered Saline with 0.02% ProClin 300.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Human Anti-TNF alpha Antibody is a research grade biosimilar of the monoclonal antibody drug infliximab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request. This product is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic infliximab antibody clone cA2. This antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-infliximab antibodies, for example HCA214 and HCA216. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-infliximab antibody in IgG1 format as a reference standard, for example HCA213 or HCA233. Infliximab, also known as Remicade, is a chimeric IgG1 kappa monoclonal antibody approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis and ulcerative colitis. This therapeutic antibody is directed against TNF alpha and acts by blocking the binding of TNF alpha to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases. This product is NOT FOR THERAPEUTIC USE. View a summary of supporting anti-infliximab antibody products

Cachectin, TNF, TNF-a, TNF-alpha, TNFA, TNFSF2, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2